Ora Schueler-Furman at The Hebrew University of Jerusalem
The Schueler-Furman lab focuses on the structural basis of peptide (short linear motif)-mediated protein interactions and their regulatory biological roles. Complemented by biophysical characterization, we aim at building a model of the atomic details of regulation, to identify natural substrates, and the targeted design of specific modulators for the study of the biological importance of an interaction. For this we develop advanced cutting edge modeling tools (e.g. Rosetta FlexPepDock and more).
This project involves the calibration, development and application of our modeling tools to characterize key E3 Ligases and DUBs. Together with information from high throughput experiments and sequence analysis (from other ITN members), we aim at providing a detailed model of the substrates and substrate specificities. Secondments of this PhD include the Davey lab (refinement of motif definitions by integration of structure and sequence information), as well as GSK (Markus Queisser lab; (validation and extension of our designs with the PROTAC technology).
Ora Schueler-Furman
Institute for Medical Research Israel-Canada
The Hebrew University of Jerusalem
