Petra Beli at Institute of Molecular Biology in Mainz
The Beli laboratory develops and employs quantitative mass spectrometry-based proteomics approaches to characterize ubiquitin signaling in nuclear protein quality control and DNA damage response.
The family of HECT-type ubiquitin ligases has been implicated in human disorders including neurodegeneration and cancer. In this project, we will define substrate specificity principles for nuclear HECT-type ubiquitin ligases and characterize the functional role of selected ubiquitin ligase – substrate relations in proteome dynamics and quality control.
Dynamic protein ubiquitination and deubiquitination plays an essential role in the regulation of DNA repair and genome stability maintenance. In this project, we will study the regulation and substrate specificity of deubiquitinating enzymes in DNA damage response
